MANAGEMENT OF AUEOUS RADIOACTIVE WASTES IN THE PRODUCTION OF 18F-LABELED RADIOPHARMACEUTICALS
Article Sidebar
Main Article Content
Abstract
In the present work, the accumulation of long-lived radionuclides in 18O-enriched water at the production of 18F-labeled radiopharmaceuticals using IBA Cyclone 18/9 cyclotron was studied. Various mechanisms of long-lived radionuclides accumulation in regenerated water are considered. The technology for the purification of regenerated water by distillation at atmospheric pressure was developed, which manifests effective elimination of γ-emitting radionuclides. It was shown, that after distillation the specific activity of β-emitting radionuclide 3H, as well as degree of 18O-enrichment are not reduced. Distillate of the regenerated 18O [H2O] is not acceptable for reuse in the production of 18F-labeled radiopharmaceuticals. The results obtained are of vital importance for the optimization of radioactive waste management procedures in production of [18F] radiopharmaceuticals using IBA Cyclone 18/9 HC cyclotron and, consequently, for minimization of radiation exposure of personnel.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Peller, P. PET-CT and PET-MRI in Oncology: A Practical Guide (Medical Radiology / Diagnostic Imaging) / P. Peller, R. Subramaniam, A. Guermazi // Springer Science & Business Media. – 2012. – P. 470.
Recommendation on the use of 18F-FDG PET in oncology / J.W. Fletcher [et al.] // J. Nuclear Medicine. – 2008. – Vol. 49, № 3. – P. 480–508.
Radionuclide impurities in proton-irradiated [18O]H2O for the production of 18F−: Activities and distribution in the [18F]FDG synthesis process / L. Bowden [et al.] // Applied Radiation and Isotopes. – 2009. – Vol. 67, № 2. – P. 248–255.
Berridge, M.S. Designs and use of silver [18O]water targets for [18F]fluoride production / M.S. Berridge, R. Kjellstrom // Applied Radiation and Isotopes. – 1999. – Vol. 50, № 4. – P. 699–705.
Позитронно-эмиссионная томография. Ч. 1 : Характеристика метода. Получение радиофармпрепаратов / С.Д. Бринкевич [и др.] // Медико-биологические проблемы жизнедеятельности. – 2013. – № 2(10) – С. 129–137.
Radioactive byproducts in [18O]H2O used to produce 18F for [18F]FDG synthesis/ Ito Shigeki [et al.] // Applied Radiation and Isotopes. – 2006. – Vol. 64, № 3. – P. 298–305.
Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) routine production / M. Marengo [et al.] // Applied Radiation and Isotopes. – 2008 – Vol. 66, № 3. – P. 295–302.
Radionuclidic purity test in 18F radiopharmaceuticals production process / T. Dziel [et al.] // Applied Radiation and Isotopes. – 2016. – Vol. 109, № 2. – P. 242–246.
Примесные радионуклиды в производстве радиофармпрепаратов на основе 18F / C.А. Добровольский [и др.] // Вестник Полоцкого государственного университета. Серия С, Фундаментальные науки. – 2017. – № 4. – C. 64–72.
Guarino, P. Gamma-ray spectrometric characterization of waste activated target components in a PET cyclotron / P. Guarino [et al.] // Cyclotrons and Their Applications – 2007 : Eighteenth International Conference, Giardini Naxos, 01–05. 10. 2007. Italy. – Giardini Naxos, 2007. – P. 295–297.
Using a clinical linac to determine the energy levels of 92mNb via the photonuclear reaction / M. Aygun [et al.] // Applied Radiation and Isotopes. – 2016. – Vol. 115, № 1. – P. 97–99.
Gillies, J.M. Analysis of metal radioisotope impurities generated in [18O]H2O during the cyclotron production of fluorine-18 / J.M. Gillies, N. Najim, J. Zweit // Applied Radiation and Isotopes. – 2006. – Vol. 64, № 4. – P. 431–434.
Al Rayyes, A.H. Enriched water-H2 18O purification to be used in routine 18FDG production / A.H. Al Rayyes // Nukleonika. – 2010. – Vol. 55, № 3. – P. 401–405.
Schueller, M.J. Separating long-lived metal ions from 18F during H2 18O recovery / M.J. Schueller,
D.L. Alexoff, D.J. Schlyer // Nuclear Instruments and Methods in Physics Research B. – 2007. – Vol. 261. – P. 795–799.