IMPURITY RADIONUCLIDES AT A RADIOPHARMACEUTICAL PRODUCTION BASED ON A 18F
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Abstract
The distribution of radionuclides in various cartridges during 18F-fluorodeoxyglucose and 18F-choline manufacture using IBA Cyclone 18/9 cyclotron was investigated in order to develop evidence-based concept of long-term storage of radioactive waste of radiopharmaceuticals for positron emission tomography. Isotopic composition of long-lived (t1/2 = 10–312 days) radionuclides was detected. It was shown that the shelf life of QMA cartridges should be at least six months. Various mechanisms of radionuclides of metals entering in cartridges at the synthesis of radiopharmaceuticals based on 18F was discussed.
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