MANAGEMENT OF AUEOUS RADIOACTIVE WASTES IN THE PRODUCTION OF 18F-LABELED RADIOPHARMACEUTICALS
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Abstract
In the present work, the accumulation of long-lived radionuclides in 18O-enriched water at the production of 18F-labeled radiopharmaceuticals using IBA Cyclone 18/9 cyclotron was studied. Various mechanisms of long-lived radionuclides accumulation in regenerated water are considered. The technology for the purification of regenerated water by distillation at atmospheric pressure was developed, which manifests effective elimination of γ-emitting radionuclides. It was shown, that after distillation the specific activity of β-emitting radionuclide 3H, as well as degree of 18O-enrichment are not reduced. Distillate of the regenerated 18O [H2O] is not acceptable for reuse in the production of 18F-labeled radiopharmaceuticals. The results obtained are of vital importance for the optimization of radioactive waste management procedures in production of [18F] radiopharmaceuticals using IBA Cyclone 18/9 HC cyclotron and, consequently, for minimization of radiation exposure of personnel.
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