APPLICATION ANALYSIS OF THE GAMMA-BETA SPECTROMETER MKS-AT1315 TO CONTROL UNWANTED RADIONUCLIDES, FORMED DURING THE PRODUCTION OF RADIOPHARMACEUTICALS

Main Article Content

A. KIYKO
S. VABISHCHEVICH
N. VABISHCHEVICH
D. BRINKEVICH

Abstract

Simultaneous measurements of γ- and β-emitting radionuclides in regenerated water and sorption purification cartridges used in the production of radiopharmaceuticals based on 18F were carried out with the MKSAT-1315 spectrometer. It was found that the bands observed in the gamma-spectra are due to isotopes of cobalt 55Co, 56Co, 58Co, 57Co, nickel 57Ni, manganese 54Mn and zinc 65Zn, the prospects of using the gamma-beta spectrometer MKS-AT1315 for operational control of the content of undesirable technological radionuclides in the production of radiopharmaceuticals based on 18F are shown.

Article Details

How to Cite
KIYKO, A., VABISHCHEVICH, S., VABISHCHEVICH, N., & BRINKEVICH, D. (2023). APPLICATION ANALYSIS OF THE GAMMA-BETA SPECTROMETER MKS-AT1315 TO CONTROL UNWANTED RADIONUCLIDES, FORMED DURING THE PRODUCTION OF RADIOPHARMACEUTICALS. Vestnik of Polotsk State University. Part C. Fundamental Sciences, (1), 44-48. https://doi.org/10.52928/2070-1624-2023-40-1-44-48
Section
Электрофизика, электрофизические установки (технические науки)
Author Biographies

S. VABISHCHEVICH, Euphrosyne Polotskaya State University of Polotsk

канд. физ.-мат. наук, доц.

D. BRINKEVICH, Belarusian State University, Minsk

канд. физ.-мат. наук

References

Brinkevich, S. D., Sukonko, O. G., Chizh, G. V., & Naumovich, A. S. (2013). Pozitronno-emissionnaya tomografiya. Chast' 1: Kharakteristika metoda. Poluchenie radiofarmpreparatov [Positron emission tomography. Part 1: Method description. Production of radiopharmaceuticals]. Mediko-biologicheskie problemy zhiznedeyatel'nosti [Medical and Biological Problems of Life Activity], 2(10), 129–137. (In Russ., abstr. in Engl.).

Brinkevich, S. D., Brinkevich, D. I., & Kiyko, A. N. (2020). Activation Radionuclides in the Process of Irradiation of a Niobium Target at the Cyclone 18/9 HC Cyclotrone. Physics of Atomic Nuclei, 83(12), 1732–1737. DOI: 10.1134/S1063778820090045.

Brinkevich, D. I., Brinkevich, S. D., Vabishchevich, S. A., Krot, V. O., & Maliborskii, A. Ya. (2019). Dolgozhivushchie β-izluchayushchie radionuklidy pri proizvodstve radiofarmpreparatov na osnove 18F [Long-living β-radiating radionuclides in the manufacture of radiopharmatic drugs based on 18F]. Vestnik Polotskogo gosudarstvennogo universiteta. Seriya C, Fundamental'nye nauki [Herald of Polotsk State University. Series С. Fundamental sciences], (4), 67–76.

Brinkevich, D. I., Maliborski, A. Ya., & Brinkevich, S. D. (2019). Activation of the cooling circuit water of the Cyclone 18/9-HC cyclotron during the production of 18F. Physics of atomic nuclei, 82(12), 1714–1720. DOI: 10.1134/S1063778819120044.

Ivanyukovich, A. A., Soroka, S. A., Krot, V. O., Brinkevich, D. I., Brinkevich, S. D., Chizh, G. V., & Sverdlov, R. L. (2018). Ochistka [18F]ftorida ot dolgozhivushchih radionuklidov pri proizvodstve [18F]ftordezoksiglyukozy [Purification of [18F]fluoride from long-lived radionuclides in production of [18F]fluorodeoxyglucose]. Medicinskaya fizika [Medical Physics], 4(80), 59–65. (In Russ., abstr. in Engl.).

Krot, V. O., Brinkevich, S. D., Brinkevich, D. I., & Ivanyukovich, A. A. (2021). Separation of Long-Lived Radionuclides on QMA Light Anion-Exchange Cartridge in Manufacture of Radiopharmaceutical Preparations Based on 18F [Radiochemistry], 63(2), 235–242. DOI: 10.1134/S1066362221020144.

Bowden, L., Vintro, L. L., Mitchell, P. I., O`Donnell, R. G., Seymour, A. M., & Duffy, G. J. (2009). Radionuclide impurities in proton-irradiated [18O]H2O for the production of 18F-: Activities and distribution in the [18F]FDG synthesis process. Applied Radiation and Isotopes, 67(2). (248–255). DOI: 10.1016/j.apradiso.2008.10.015.

Gillies, J. M., Najim, N., & Zweit, J. (2006). Analysis of metal radioisotope impurities generated in [18O]H2O during the cyclotron production of fluorine-18. Applied Radiation and Isotopes, 64(4), 431–434. DOI: 10.1016/j.apradiso.2005.08.008.

Shigeki Ito, Hitoshi Sakane, Shizuhiko Deji, Takuya Saze, & Kunihide Nishizawa. (2006). Radioactive byproducts in [18O]H2O used to produce 18F for [18F]FDG synthesis. Applied Radiation and Isotopes, 64(3), 298–305. DOI: 10.1016/j.apradiso.2005.10.001.

Guarino, P., Rizzo, S., Tomarchio, E., & Greco, D. (2007). Gamma-ray spectrometric characterization of waste activated target components in a PET cyclotron. Cyclotrons and Their Applications–2007 (295–297). Giardini Naxos, Italy.