LONG-LIVING β-RADIATING RADIONUCLIDES IN THE MANUFACTURE OF RADIOPHARMATIC DRUGS BASED ON 18F
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Abstract
The accumulation of long-lived β-emitting radionuclides in 18O-enriched water in the production of radiopharmaceuticals based on 18F using the IBA Cyclone 18/9 HC cyclotron was studied. There is a linear correlation of 3H activity with 18F activity accumulated on the cyclotron. With durations of exposure exceeding the halflife of 18F (t1/2 = 110 min), the ratio of the activities of tritium and 18F increases. It is due to the decay of the 18F during irradiation. The main share of 3H (about 95%) remains in the regenerated water. 1,6% of the accumulated tritium activity is carried away from the synthesis zone with gases and water vapor. It is about 4∙10-8 from the 18F activity accumulated on the cyclotron. Waste containing tritium (regenerated water in vials) can be considered as a very low level activity waste. With an increase in the accumulated target dose above 2500 μA∙h, the corrosion/erosion of the target materials increases. It leads to a sharp increase in the concentration of unwanted radionuclides in the regenerated water, sorption purification cartridges and the finished dosage form. The concentration of tritium does not increase significantly, Series of maxima appear in the low- and highenergy part of the spectrum (in addition to the maximum due to tritium) in the β-spectra of regenerated water [18O] H2O and finished RFP [18F] NaF. The results obtained are important for optimizing the methods of radioactive waste management in the production of radiopharmaceuticals based on 18F with using the IBA Cyclone 18/9 HC cyclotron and, as a result, minimizing personnel dose rates.
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