IMPURITY RADIONUCLIDES AT A RADIOPHARMACEUTICAL PRODUCTION BASED ON A 18F
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Abstract
The distribution of radionuclides in various cartridges during 18F-fluorodeoxyglucose and 18F-choline manufacture using IBA Cyclone 18/9 cyclotron was investigated in order to develop evidence-based concept of long-term storage of radioactive waste of radiopharmaceuticals for positron emission tomography. Isotopic composition of long-lived (t1/2 = 10–312 days) radionuclides was detected. It was shown that the shelf life of QMA cartridges should be at least six months. Various mechanisms of radionuclides of metals entering in cartridges at the synthesis of radiopharmaceuticals based on 18F was discussed.
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References
Oehr, P. PET and PET-CT in oncology / P. Oehr, H.J. Biersack, R.E. Coleman. – Berlin : Springer, 2004. – 357 p.
Позитронно-эмиссионная томография / С.Д. Бринкевич [и др.] // Медико-биологические проблемы жизнедеятельности. – 2013. – № 2(10) – Ч. 1 : Характеристика метода. Получение радиофармпрепаратов. – С. 129–137.
Кодина, Г.Е. Методы получения радиофармацевтических препаратов и радионуклидных генераторов для ядерной медицины / Г.Е. Кодина, Р.Н. Красикова. – М. : МЭИ, 2014. – 282 с.
Firestone, R.B. Table of radioactive isotopes/ R.B. Firestone, V.S.Shirley – New York: John Wiley and Sons, – 1988.
Физико-химические свойства элементов : справ. / под ред. Г.В. Самсонова. – Киев : Наукова думка, 1965. – 807 с.
Radionuclide characterization studies of radioactive waste produced at high-energy accelerators / L. Ulrici [et al.] // Nuclear Instruments and Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. – 2006. – V. 562, № 2. – P. 596–600.
Gamma-ray spectrometric characterization of waste activated target components in a PET cyclotron / P. Guarino [et al.] // Cyclotrons and Their Applications – 2007 : Eighteenth International Conference. – P. 295–297.
Guarino, P. Measurement of activity of the predominant gamma-emitting radionuclides in activated components of a medical cyclotron plant [Electronic resource] / P. Guarino, S. Rizzo, E. Tomarchio.
Белов, А.Г. Интегральные сечения фотоядерных реакций в области гигантского дипольного резонанса / А.Г. Белов [и др.]. – Дубна : ОИЯИ, 2000. – 11 с. – (Препринт / Объед. ин-т ядер. исслед. ; Р15-2000-15).
Niobium sputtered Havar foils for the high-power production of reactive [18F]fluoride by proton irradiation of [18O]H2O targets / J.S. Wilson [et al.] // Applied Radiation and Isotopes. – 2008. – V. 66, № 5. – P. 565–570.
Measurement of the residual radioactivity induced in the front foil of a target assembly in a modern medical cyclotron / R.G. O’Donnell [et al.] // Applied Radiation and Isotopes. – 2004. – V. 60, № 2–4. – P. 539–542.
Лаврухина, А.К. Ядерные реакции в космически телах / А.К. Лаврухина. – М. : Наука, 1972. – 253 с.
Beryllium-7 wet deposition variation with storm height, synoptic classification, and tree canopy state in the mid-Atlantic USA / D.L. Karwan [et al.] // Hydrological Processes. – 2016. – V. 30, № 1 – P. 75–89.
Gillies, J.M. Analysis of metal radioisotope impurities generated in [18O]H2O during the cyclotron production of fluorine-18 / J.M. Gillies, N. Najim, J. Zweit // Applied Radiation and Isotopes. – 2006. – V. 64, № 4. – P. 431–434.
Radioactive byproducts in [18O]H2O used to produce 18F for [18F]FDG synthesis / Ito Shigeki [et al.] // Applied Radiation and Isotopes. – 2006. – V. 64, № 3. – P. 298–305.
Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) routine production / M. Marengo [et al.] // Applied Radiation and Isotopes. – 2008. – V. 66, № 3. – P. 295–302.
Radionuclide impurities in proton-irradiated [18O]H2O for the production of 18F−: Activities and distribution in the [18F]FDG synthesis process / L. Bowden [et al.] // Applied Radiation and Isotopes. – 2009. – V. 67, № 2 – P. 248–255.
Al Rayyes, A.H. Enriched water-H2 18O purification to be used in routine 18FDG production / A.H. Al Rayyes // Nukleonika. – 2010. – V. 55, № 3. – P. 401–405.
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