LONG-LIVING β-RADIATING RADIONUCLIDES IN THE MANUFACTURE OF RADIOPHARMATIC DRUGS BASED ON 18F
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Abstract
The accumulation of long-lived β-emitting radionuclides in 18O-enriched water in the production of radiopharmaceuticals based on 18F using the IBA Cyclone 18/9 HC cyclotron was studied. There is a linear correlation of 3H activity with 18F activity accumulated on the cyclotron. With durations of exposure exceeding the halflife of 18F (t1/2 = 110 min), the ratio of the activities of tritium and 18F increases. It is due to the decay of the 18F during irradiation. The main share of 3H (about 95%) remains in the regenerated water. 1,6% of the accumulated tritium activity is carried away from the synthesis zone with gases and water vapor. It is about 4∙10-8 from the 18F activity accumulated on the cyclotron. Waste containing tritium (regenerated water in vials) can be considered as a very low level activity waste. With an increase in the accumulated target dose above 2500 μA∙h, the corrosion/erosion of the target materials increases. It leads to a sharp increase in the concentration of unwanted radionuclides in the regenerated water, sorption purification cartridges and the finished dosage form. The concentration of tritium does not increase significantly, Series of maxima appear in the low- and highenergy part of the spectrum (in addition to the maximum due to tritium) in the β-spectra of regenerated water [18O] H2O and finished RFP [18F] NaF. The results obtained are important for optimizing the methods of radioactive waste management in the production of radiopharmaceuticals based on 18F with using the IBA Cyclone 18/9 HC cyclotron and, as a result, minimizing personnel dose rates.
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References
Позитронно-эмиссионная томография. Ч. 1 : Характеристика метода. Получение радиофармпрепаратов / С.Д. Бринкевич [и др.] // Медико-биологические проблемы жизнедеятельности. – 2013. – № 2. – С. 129–137.
Кодина, Г.Е. Методы получения радиофармацевтических препаратов и радионуклидных генераторов для ядерной медицины / Г.Е. Кодина, Р.Н. Красикова. – М. : МЭИ, 2014. – 282 с.
Peller, P. PET-CT and PET-MRT in Oncology: A Practical Guide (Medical Radiology) / P. Peller, R. Subramaniam, A. Guermazi // Springer Science & Business Media. – 2012. – 470 p.
Обращение с водными радиоактивными отходами при производстве радиофармпрепаратов на основе 18F / В.О. Крот [и др.] // Вестник Полоцкого государственного университета. Серия С, Фундаментальные науки. – 2018. – № 4. – C. 128–134.
Radionuclide impurities in proton-irradiated [18O]H2O for the production of 18F-: Activities and distribution in the [18F]FDG synthesis process / L. Bowden [et al.] // Applied Radiation and Isotopes. – 2009. – V. 67. – P. 248–255.
Tritium in [18O]water containing [18F]fluoride for [18F]FDG synthesis / S. Ito [et al.] // Applied Radiation and Isotopes. – 2004. – V. 61. – P. 1179–1183.
Бондарева, Л.Г. Накопление трития организмами по экологическим пищевым цепочкам / Л.Г. Бондарева // Радиохимия – 2018 : сб. тезисов IX Рос. конф., 17–21 сент. 2018 г., СПб. – СПб., 2018. – С. 208.
Кузнецова, Н.А. О вопросах дезактивации оборудования от трития / Н.А. Кузнецова, М.В. Ерофеева // Радиохимия – 2018 : сб. тезисов IX Рос. конф., 17–21 сент. 2018 г., СПб. – СПб., 2018. – С. 410.
Очистка [18F]фторида от долгоживущих радионуклидов при производстве [18F]фтордезоксиглюкозы / А.А. Иванюкович [и др.] // Медицинская физика. – 2018. – № 4(80). – С. 59–65.
Долгоживущие радионуклиды при производстве [18F]фторхолина для ПЭТ-диагностики / П.В. Тылец [и др.] // Известия НАН Беларуси. Серия химических наук. – 2018. – № 3. – С. 359–368.
Monte Carlo simulation and radiometric characterization of proton irradiated [18O]H2O for the treatment of the waste streams originated from [18F]FDG synthesis process / R. Remetti [et al.] // Applied Radiation and Isotopes. – 2011. – V. 69. – P. 1046–1051.
Quantification of the activity of tritium produced during the routine synthesis of 18F fluorodeoxyglucose for positron emission tomography / C. Marshall [et al.] // J. Radiological Protection. – 2014. – V. 34. – P. 435–444.
Evaluated Nuclear. – Mode of access: https://www-nds.iaea.org/exfor/endf.htm.
Niobium sputtered Havar foil for the high-power production of reactive [18F]fluoride by proton irradiation of [18O]H2O targets / J.S. Wilson [et al.] // Applied Radiation and Isotopes. – 2008. – V. 66. – P. 565–570.
Физико-химические свойства элементов : справочник / под ред. Г.В. Самсонова. – Киев, 1965. – С. 655–668.
Assessment of atmospheric tritium concentration levels due to the normal operation of a radiopharmaceutical production unit (UPPR) / C.M. Peixoto, V.M.F. Jacomino, V.S. Dias // 2011 Intern. Nuclear Atlantic Conf. – INAC 2011 ; Belo Horizonte, MG, Brazil, 24-28 Oct. 2011. – 7 p.
Measurement of the induced radionuclides in production of radiopharmaceuticals for positron emission tomography (PET) / S. Mochizuki [et al.] // J. Nuclear Science and Technology. – 2006. – V. 43, № 4. – P. 348–353.
Radionuclide impurities in [18F]F- and [18F]FDG for positron emission tomography / M. Kohler [et al.] // Applied Radiation and Isotopes. – 2013. – V. 81. – P. 268–271.
Райхардт, К. Растворители и эффекты среды в органической химии / К. Райхардт. – М. : Мир, 1991. – 763 с.
Требования к обеспечению радиационной безопасности персонала и населения при обращении с радиоактивными отходами : Санитарные нормы и правила : утв. постановлением М-ва здравоохранения Респ. Беларусь № 142 от 31.12.2015.
Примесные радионуклиды в производстве радиофармпрепаратов на основе 18F / С.А. Добровольский [и др.] // Вестник Полоцкого государственного университета. Серия С, Фундаментальные науки. – 2017. – № 4. – C. 64–72.
Долгоживущие радионуклиды в производстве 2-[18F]фтордезоксиглюкозы / Д.И. Бринкевич [и др.] // Медицинская физика. – 2018. – № 1. – С. 80–88.
Long-lived radionuclides in the production of 18F-labeled radiopharmaceuticals / V.O. Krot [et al.] // 13th Int. Symposium on the Synthesis and Application of Isotopically Labelled Compounds, Prague, Czech Republic, 3-7 June 2018. – Prague, 2018. – P. 43.
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